Definition
The Local Interaction Score (LIS) counts the fraction of inter-group residue pairs with PAE below a cutoff threshold, measuring how confidently the model predicts the spatial relationship between residue groups. For each qualifying pair, the contribution is(cutoff - PAE) / cutoff, producing a score between 0 and 1. The result is negated so that lower energy corresponds to stronger predicted interactions. When intensive=True, the score is averaged over qualifying pairs; when intensive=False, it is summed (extensive mode).
Parameters
FoldingOracle
required
The oracle to use for the energy term.
list[list[Residue]]
required
Which residues to include in the first and second group.
float
default:"12.0"
The cutoff value for the PAE, in Angstroms, below which the interaction is considered “local”.
bool
default:"True"
If True, the LIS is averaged over the number of residue pairs, otherwise it’s an extensive sum.
bool
default:"True"
If a new residue is added next to a residue included in this energy term, this dictates whether that new residue could then be added to this energy term.
float
default:"1.0"
The weight of the energy term.
str | None
default:"None"
Optional name to append to the energy term name.
Methods
compute
ParametersOraclesResultDict
required